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Even though these decreased levels of exposure are more unlikely to provide the typical ‑reactions observed with oral metronidazole, the potential for these together with other reactions cannot be excluded presently.

disulfiram raises toxicity of metronidazole topical by decreasing metabolism. Small/Significance Mysterious. Increased CNS & cardiac toxicity with oral metronidazole and disulfiram; less likely to occur with topical administration thanks to small absorption.

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Administer with warning in patients with CNS conditions on account of danger of numbess or paresthesia of an extremity

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The next adverse reactions and altered laboratory checks have been described With all the oral or parenteral use of metronidazole:

Oral metronidazole has become claimed to potentiate the anticoagulant impact jne togel of warfarin and other coumarin anti‑coagulants, leading to a prolongation of prothrombin time.

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There has been no working experience thus far with using METROGEL-VAGINAL in pregnant people. Metronidazole crosses the placental barrier and enters the fetal circulation fast. No fetotoxicity or teratogenicity was observed when metronidazole was administered orally to Expecting mice at 6 jnetoto instances the proposed human dose (determined by mg/m2); nevertheless, in one tiny review where the drug was administered intraperitoneally, some intrauterine deaths have been observed. The connection of such conclusions to the drug is unfamiliar.

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